| A071401-CIRB | Phase II Trial of SMO/AKT/NF2 inhibitors in Progressive Meningiomas with SMO/AKT/NF2 Mutations | Open |
| CA209-204 | Multi-Center Phase 2 Open-Label Study to Evaluate Safety and Efficacy in Subjects with Melanoma Metastatic to the Brain treated with Nivolumab in Combination with Ipilimumab followed by Nivolumab Monotherapy | Open |
| COG-ACNS0831 | Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with
Newly Diagnosed Ependymoma Ages 1 to 21 years | Open |
| COG-ACNS1123 | Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized
Central Nervous System Germ Cell Tumors (CNS GCT) | Open |
| COG-ANBL1221 | A Phase II Randomized Trial of Irinotecan/Temozolomide with Temsirolimus (NSC# 683864, IND# 61010) or Chimeric 14.18 Antibody (ch14.18) (NSC# 623408, IND# 4308) in Children with Refractory, Relapsed or Progressive Neuroblastoma | Open |
| COG-ANBL1232 | Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma | Open |
| COGACNS0332 | Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients | Open |
| D6410C00001 | A Phase I, First-Time-in Human Study of MEDI9197, a TLR 7/8 Agonist, Administered Intratumorally in Subjects with Solid Tumor Cancer | Open |
| LCCC1308 | Engineering Reprogrammed Patient-derived Neural Stem Cells for Novel Malignant Glioma Therapy | Open |
| LCCC1419 | Establishment of Breast Cancer Brain Metastases (BCBM) Registry to Support Research of Molecular Drivers of BCBM | Open |
| LCCC1538 | Geriatric Assessment Reporting in Real Time (GARRT) in non-electively hospitalized older cancer patients: feasibility, impact, and clinician acceptance. | Open |
| LCCC1540 | Prospective Evaluation of Patient-Reported Xerostomia After Whole Brain Radiation. | Open |
| LCCC1602 | Health services use and social outcomes of adult survivors of childhood cancer | Open |
| LOXO-TRK-15002 | A Phase II Basket Study of the Oral TRK Inhibitor LOXO-101 in Subjects with NTRK Fusion-Positive Tumors | Open |
| MCC-16962 | A Phase I Trial of Dose Escalation of Metformin in Combination with Vincristine, Irinotecan, and Temozolomide in Children with Relapsed or Refractory Solid Tumors | Open |
| MIBG-EXPANDED-ACCESS | An Open Label, Expanded Access Protocol Using 131i-Metaiodobenzylguanidine (131i-Mibg) Therapy In Patients With Refractory Neuroblastoma, Pheochromocytoma, Or Paraganglioma | Open |
| ML28897PRO/02 | My Pathway: An Open-Label Phase IIA Study Evaluating Trastuzumab/Pertuzumab, Erlotinib, Vemurafenib/Cobimetinib, and Vismodegib in Patients who have Advanced Solid Tumors with Mutations or Gene Expression Abnormalities Predictive of Response to one of these Agents. | Open |
| N107C-CIRB | N107C, A Phase III Trial of Post-Surgical Stereotactic Radiosurgery (SRS) Compared with Whole Brain Radiotherapy (WBRT) for Resected Metastatic Brain Disease | Open (affiliates only) |
| NRG-CC001 | A randomized Phase III Trial of Memantine and Whole-Brain Radiotherapy with or without Hippocampal Avoidance in patients with Brain Metastases | Open |
| PCRC-14-07 | Caregiver-‐guided pain management training in palliative care | Open |
| VEG116731 | A Phase II Study of Pazopanib (GW786034, NSC# 737754) in Children, Adolescents and Young Adults with Refractory Solid Tumors | Open |