| 13-0736 | Improving endocrine therapy utilization in racially diverse populations | Open |
| 15-102-14 | A Phase 3 Open-Label, Randomized, Multicenter Study of NKTR-102 versus Treatment of Physician’s Choice (TPC) in Patients with Metastatic Breast Cancer Who Have Stable Brain Metastases and Have Been Previously Treated with an Anthracycline, a Taxane, and Capecitabine | Open |
| 15-2304 | Implementing Breast Cancer Care Efficiency in Zambia through Specialized Health Provider Training and mhealth Evaluation of Patient Outcomes | Open |
| 16-1634 | Comparative Effectiveness of Breast Cancer Screening, Diagnosis, and Management in Community Practice | Open |
| 16-1775 | Developing a Medication Assistance Program for Uninsured and Under-insured Patients with Metastatic Breast Cancer: Key Informant Conference Participant Data
| Open |
| 17-2168 | Carolina Mammography Registry (CMR) | Open |
| 201209135 | A Phase II Study of Neratinib Alone and in Combination with Fulvestrant in Metastatic HER2 Non-amplified but HER2 Mutant Breast Cancer | Open |
| A011401 | Randomized Phase III Trial Evaluating the Role of Weight Loss in Adjuvant Treatment of Overweight and Obese Women with Early Breast Cancer
| Open |
| A011502-CIRB | A Randomized Phase III Double Blinded Placebo Controlled Trial of Aspirin as Adjuvant Therapy for Node Positive HER2 Negative Breast Cancer: The ABC Trial | Open |
| A171603 | Feasibility of an Electronic Geriatric Assessment (EGA) for Older Adults with Cancer | Open |
| A211201-REX | CHANGE IN MAMMOGRAPHIC DENSITY WITH METFORMIN USE:
A COMPANION STUDY TO NCIC STUDY MA.32 | Open (affiliates only) |
| A221405 | A Study Evaluating the Pregnancy Outcomes and Safety of Interrupting Endocrine Therapy for Young Women with Endocrine Responsive Breast Cancer Who Desire Pregnancy (POSITIVE) | Open |
| AFT-25 | Comparison of Operative to Monitoring and Endocrine Therapy (COMET) Trial for Low Risk DCIS: a Phase III Prospective Randomized Trial | Open |
| AFT-25-REX | Comparison of Operative to Monitoring and Endocrine Therapy (COMET) Trial for Low Risk DCIS: a Phase III Prospective Randomized Trial | Open |
| ALTERNATE/A011106 | ALTernate approaches for clinical stage II or III Estrogen Receptor positive breast cancer NeoAdjuvant TrEatment (ALTERNATE) in postmenopausal women: A Phase III Study | Open |
| AMC-095 | A Phase I Study of Ipilimumab and Nivolumab in Advanced HIV Associated Solid Tumors with an Expansion Cohort in HIV Associated Solid Tumors and a Cohort of HIV-Associated Classical Hodgkin Lymphoma | Open |
| APEC1621SC | NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) | Open |
| B2151009 | Phase 1B Study to Assess the Safety, Tolerability, and Clinical Activity of Gedatolisib in Combination with Palbociclib and Either Letrozole or Fulvestrant in Women with Metastatic or Locally Advanced/Recurrent Breast Cancer (MBC) | Open |
| DMT-2015-001 | A prospective, multicenter, multi-arm, clinical case collection program to acquire breast image data and establish an image library of exams for use in future research studies, training, marketing, and advance new product development efforts | Open |
| E1Z11 | A Cohort Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms (AIMSS) | Open (affiliates only) |
| E2112-CIRB | A Randomized Phase III Trial of Endocrine Therapy Plus Entinostat/Placebo in Patients with Hormone Receptor-Positive Advanced Breast Cancer | Open |
| EA1151 | Tomosynthesis Mammographic Imaging Screening Trial (TMIST) | Open |
| GO30140 | An Open-Label, Multicenter Phase Ib Study of the Safety and Tolerability of Atezolizumab (ANTI-PD L1 Antibody) Administered in combination with Bevacizumab and/or other Treatments in Patients with Solid Tumors. | Open |
| INCAGN1876-201 | A Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 in Combination with Immune therapies in Subjects with Advanced or Metastatic Malignancies | Open |
| INO-VT-464-CL-006 | A Phase 1/2 Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of VT-464 in Patients with Advanced Breast Cancer | Open |
| LCCC1405 | Comparison of the specificity of acoustic angiography (Micro-tumor detection by quantifying tumor-induced vascular abnormalities) to the specificity of conventional ultrasound | Open |
| LCCC1410 | Impact of physical activity on biomarkers of aging and body composition among breast cancer survivors age 65 and older
| Open |
| LCCC1414 | Evaluation of stationary digital breast tomosynthesis in a screening call back population and in patients with calcifications | Open |
| LCCC1419 | Establishment of Breast Cancer Brain Metastases (BCBM) Registry to Support Research of Molecular Drivers of BCBM | Open |
| LCCC1501 | The Impact of Real Time, Three-Dimensional Photographic Simulation on Satisfaction with Decisions about Breast Reconstruction | Open |
| LCCC1512 | Evaluation of the accuracy of new-generation pedometers in older adult patients with advanced cancers | Open |
| LCCC1535 | Understanding Treatment Decision-making and Psychological Distress in Patients with Advanced Cancer | Open |
| LCCC1537 | Physical activity to maintain quality of life and physical function in women with metastatic breast cancer: a pilot study | Open |
| LCCC1540 | Prospective Evaluation of Patient-Reported Xerostomia After Whole Brain Radiation. | Open |
| LCCC1545 | Computerized Cognitive Behavioral Therapy in Recently Treated Breast Cancer Patients | Open |
| LCCC1611 | Establishment of a novel breast cancer cohort in Malawi | Open |
| LCCC1616 | Developing a medication assistance program for uninsured and underinsured patients with metastatic breast cancer | Open |
| LCCC1618 | Validation of Activity Tracker Data as a Measure of Fatigue, Symptom Burden, Physical Function and Quality of Life in Adults Receiving Taxane Therapy for Treatment of Stage II/III Breast Cancer | Open |
| LCCC1622 | A Single Arm Evaluation of False Negative Rate of Selective Image Guided Resection of Pathologically Documented Axillary Lymph Node Metastases | Open |
| LCCC1623 | Interviewing cancer patients and caregivers about using symptom questionnaires to improve quality of cancer care | Open |
| LCCC1630 | Get Real and HEEL Research Program | Open |
| LCCC1631 | A Qualitative Study of Patients who chose Contralateral Prophylactic Mastectomy (CPM)
| Open |
| LCCC1639 | A Non-Randomized, Non-Comparative, Open-Label, Window Trial of Entinostat in Subjects with Borderline ER/PR Positive Breast Cancer and TNBC (Part 1) or Entinostat with or without Exemestane in Subjects with Newly Diagnosed, Stage I-IIIC, Hormone Receptor Positive (HR+) Breast Cancer (Part 2) | Open |
| LCCC1642 | Plasma Circulating Tumor DNA (ctDNA) Analyses in ER+ Metastatic Breast Cancer | Open |
| LCCC1701 | A Web-based Tailored Health Behavior Intervention for Breast and Colon Cancer Survivors (eWellness) | Open |
| LCCC1719 | A Psychosocial Intervention to Improve Outcomes for Parents with Advanced Cancer | Open |
| LCCC1734 | Adaptation of the Parenting Concerns Questionnaire for Patients with Illness | Open |
| LCCC1737 | Leveraging Stakeholders’ Perspectives to Develop and Test Stakeholder Responsive Survivorship (StaRS), a Change Package for Optimizing Survivorship Care Implementation | Open |
| LCCC1749 | Impact of home-based aerobic and strength exercises during chemotherapy for early breast cancer on biomarkers of aging and patient-reported symptoms and outcomes | Open |
| LCCC1801 | A Cognitive Neuroscience Based-Assessment of Breast Cancer Survivors and Healthy Control Participants | Open |
| LCCC1802 | Randomized Trial of Parotid Sparing Whole Brain Radiation | Open |
| MCC-16962 | A Phase I Trial of Dose Escalation of Metformin in Combination with Vincristine, Irinotecan, and Temozolomide in Children with Relapsed or Refractory Solid Tumors | Open |
| MDT16075 | OsteoCool Tumor Ablation Post-Market Study (OPuS One) | Open |
| MK-3475-355-REX | A Randomized, Double-Blind, Phase III Study of Pembrolizumab (MK-3475) plus Chemotherapy vs Placebo plus Chemotherapy for Previously Untreated Locally Recurrent Inoperable or Metastatic Triple Negative Breast Cancer – (KEYNOTE-355) | Open (affiliates only) |
| ML28897PRO/02 | My Pathway: An Open-Label Phase IIA Study Evaluating Trastuzumab/Pertuzumab, Erlotinib, Vemurafenib/Cobimetinib, and Vismodegib in Patients who have Advanced Solid Tumors with Mutations or Gene Expression Abnormalities Predictive of Response to one of these Agents. | Open |
| MM-121-02-02-10 | SHERBOC: A Double-blind, Placebo-controlled, Phase 2 trial of Seribantumab Plus Fulvestrant in Postmenopausal Women with Hormone Receptor-positive, Heregulin Positive (HRG+), HER2 Negative Metastatic Breast Cancer Whose Disease Progressed After Prior Systemic Therapy | Open |
| NC-6300-001 | A Phase 1b/2 Dose-Escalation and Expansion Trial of NC-6300 (Nanoparticle Epirubicin) in Patients with Advanced Solid Tumors or Advanced, Metastatic, or Unresectable Soft Tissue Sarcoma | Open |
| NCI10013-CIRB | Randomized Phase 2 Study of Neoadjuvant Chemotherapy, Carboplatin and Paclitaxel, with or without Atezolizumab in Triple Negative Breast Cancer (TNBC) | Open |
| NCI10020-CIRB | A Phase II Open-Label, Randomized Study of PARP inhibition (olaparib) Either Alone or in Combination with Anti-PD-L1 Therapy (atezolizumab; MPDL3280A) in Homologous DNA Repair (HDR) Deficient Triple Negative Breast Cancer (TNBC) | Open |
| NRG-BR003-CIRB | A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High- Risk Node-Negative Triple-Negative Invasive Breast Cancer | Open |
| NSABP-B-46-I | A Phase III Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women with Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer | Open (affiliates only) |
| NSABP-B-54-I-REX | Phase III study evaluating palbociclib (PD-0332991), a Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor in patients with hormone-receptor-positive, HER2-normal primary breast cancer with high relapse risk after neoadjuvant chemotherapy | Open (affiliates only) |
| ONT-380-206 | Phase 2 Randomized, Double-Blinded, Controlled Study of Tucatinib vs. Placebo in Combination with Capecitabine and Trastuzumab in Patients with Pretreated Unresectable Locally Advanced or Metastatic HER2+ Breast Carcinoma (HER2CLIMB) | Open |
| PCRC-14-07 | Caregiver-‐guided pain management training in palliative care | Open |
| RETROSHAVE | Comparison of surgical techniques for obtaining negative margins in patients with breast cancer | Open |
| S1207-CIRB | Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/neu Negative Breast Cancer | Open |
| S1416-CIRB | Phase II Randomized Placebo-Controlled Trial of Cisplatin with or Without ABT-888 (Veliparib) in Metastatic Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases. | Open |
| S1418-CIRB | Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with > 1 cm Residual Invasive Cancer or Positive Lymph Nodes (>pN1mic) After Neoadjuvant Chemotherapy | Open |
| TBCRC-034 | The Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or DCIS in Patients Diagnosed with Intraductal Papilloma without Atypia or Flat Epithelial Atypia by Core Needle Biopsy | Open |
| TBCRC-037 | A Trial of Endocrine Response in Women with Invasive Lobular Breast Cancer | Open |
| TBCRC038 | Diversity in the Tumor Genome and Microenvironment as Drivers of DCIS
Progression | Open |
| Z31602 | Z 31602 - Breast and Cervical Cancer Survivorship Among HIV-Positive Women in Zambia | Open |
| Z31603 | A comparison of digital cervicography and transvaginal colposcopy | Open |